Molecular Virologist

Technical Consultant #1072

2001 - 2003 Physiome Science, Princeton, NJ

Director of Software Product Planning and Biological Sciences

Computational biology and informatics
Advanced computer simulation of complex biological systems, pathways, and networks for drug discovery .
Development of biological simulation software and predictive biomodels.
Scientific concept mining systems define new technology for defined problems.
Developed business relationships with biotechnology and pharmaceuticals clients

2001 University of Delaware Biology Department, and NSF

2000 - 2001 Management Team Establishing the Delaware Biotechnology Institute, Newark, DE, Assistant to the Director

Created budget and technical facility financial plan.
Led Scientific Advisory Board as management team representative. Led the management team strategic planning sessions.
Wrote strategies for, and sections of, successful federal center granted applications (NIH, NSF).

1990 - 1994 DuPont Merck Pharmaceutical Co., Wilmington, DE

Director of Applied Biotechnology

Supervised two research groups that formed a 52-person organization:

Managed over 25 research projects in 5 therapeutic areas.
Created a sweeping new scientific program in integrin biology.
Produced many multi-gram quantities of purified proteins for screening and structural biology.
Guided post-doctoral scientist in the creation of oocyte and patch-clamp electrophysiological assays for rapid cloning of neural cGMP-coupled receptors and drug screening.
Invented a novel yeast-l-hybrid system that rapidly cloned genes corresponding to substrate-specific yet previously unknown proteases.
Demonstrated the validity and power of single-chain antibody systems for rapidly making discovery reagents.
Developed protein-family-specific SAGE systems that profiled gene expression complexity in human disease and the changes during drug treatment.
Created novel degenerate PCR systems used to clone gene families of drug targets; including suppression PCR normalization and targeted subtractions.
Invented a unique differential display system (DDGE) that identified gene family members whose expression changes during disease progression.
Created novel oligonucleotide-directed subtraction protocols (capture) for constructing gene-family-enriched libraries.

Invited Lectures

Recombinant DNA Methods in Biotechnology: Boston College and the Genetic and Toxicology Research Society of America.
Strategies for Cloning Gene Families, University of Pennsylvania, Medical and Graduate Schools.
The Company Representative's Role as Consultant in Promoting the Adoption of Advanced Technologies. Beckman Coulter Regional Sales Meeting, Lewes, DE.

Publications

13 peer reviewed publications; 5 in-progress/under-revision; 17 additional articles published by Applied Molecular Biology and Biotechnology Resources reports during 1990-1994.