Medicinal Chemist with Custom Organic Synthesis Laboratory

Technical Consultant #1125

Organic Chemist and Medicinal Chemist with laboratory for experiments and custom organic synthesis.
Intellectual property and patent expert.
Patent infringement and patent validation expert.
Medicinal Chemist with extensive drug discovery and lead optimization accomplishments in the pharmaceutical industry.
Strong academic organic chemistry experience.
Discovered novel, potent heterocyclic and peptide mimetic enzyme inhibitors and receptor antagonists with good permeability and bioavailability properties.
Good working knowledge of biochemistry and pharmacology.
Strong patent and publication record.
Medicinal Chemistry - Pharmaceutical compound lead selection and optimization, analog synthesis.
Custom synthesis of organic molecules including pharmaceuticals and active ingredients (API), key intermediates and building blocks for medicinal chemistry.
Process research and development and production of small quantities of pharmaceutical chemicals.

Expert Witness Experience

Expert witness and fact witness: Analyzed patents, performed laboratory experiments in support of patent litigation, and testified at high-profile pharmaceutical patent trials.

Independent Consultant, 2001 - Present

Specialize in pharmaceutical patent litigation cases requiring laboratory investigation.
Organic and medicinal chemistry expert witness and fact witness in more than a dozen pharmaceutical patent litigation cases.
Testified in two high-profile cases.
Considerable patent experience. Wrote the genus and examples for the 15 U.S. patents obtained, and worked closely with patent attorneys and patent agents to construct the claims.
Consulted for intellectual property firms.
Performed experiments to establish the validity of patent claims. This work frequently involved generic drugs and patent infringement cases.
Founded chemistry laboratory located near Philadelphia, which is fully equipped to conduct custom organic synthesis and contract medicinal chemistry research. Also work as consultant in medicinal chemistry and organic chemistry.
Custom organic synthesis and medicinal chemistry; preparing compounds including enzyme inhibitors, receptor antagonists, enzyme substrates, and synthetic intermediates for the pharmaceutical and biotechnology industries.

Cephalon, Inc., West Chester, PA, Principal Chemist, Sr. Scientist - Medicinal Chemistry, 1992 - 2001

Treatment of Cerebral Ischemia and Cancer

Inhibitors

PARP: Designed novel, potent, selective heterocyclic heterocyclic inhibitors of poly(ADP-ribose)polymerase and properties.
Optimized potency and properties of screening hit to provide lead molecule. Lead compounds cross blood-brain barrier, and reduce infarct volume in cerebral ischemia.
Calpain: Designed laboratories, coordinated a multidisciplinary team of 20 biochemists, pharmacologists, cell biologists and medicinal chemists to evaluate hypotheses and plan new directions.
Designed and synthesized novel peptide-mimetic and non-peptide cell-permeable calpain inhibitors with new enzyme-reactive groups for neurodegenerative therapy.

Berlex Laboratories, Cedar Knolls, NJ, Scientist, Medicinal Chemistry, 1987 - 1992

Cardiovascular drug research and development

As project Leader directed group of medicinal chemists in synthesis of enzyme inhibitors and peptide mimetics.
Designed and synthesized highly potent endothelin converting enzyme inhibitors.
Investigated mechanism of epoxysuccinate class of cysteine protease inhibitors.
Identified novel peptide-mimetic construct which was incorporated into angiotensin II.
Performed molecular modeling on peptides, peptide mimetics, and enzyme inhibitors.

State University of New York, Stony Brook, NY, 1980 - 1987

Assistant Professor of Chemistry. Synthetic Organic and Bio-Organic Chemistry

Synthesized biologically significant natural products: Biotin, oudenone, civet acid, C-glycoside antibiotics, lignans, tetrahydroisoquinolines. Generation and utilization of a-halo ethers and oxonium ions in synthesis.
Regioselectivity of Pictet-Spengler reaction.
Determined structures of crown gall tumor metabolites.
Wrote computer software programs for literature reference retrieval and elemental analysis.

University of Wisconsin, Madison, WI, 1978 - 1980

NIH Postdoctoral Fellow. Organic Synthesis and Structure Elucidation

Synthesized natural products; introduced chirality via microbial transformation.
Isolated and elucidated structures of compounds with smooth muscle-contracting activity (Leukotriene and G-acid) from animal tissue; determined mechanism of action.
Performed smooth-muscle contractility assays.

University of California, Graduate Student, Organic Chemistry, Berkeley, CA, 1972 - 1978