Neurobiologist Consultant for Biotherapeutic Drug Discovery and Development

Technical Consultant #1490

Eight (8) years of experience in biotherapeutic drug discovery and development with a focus on neurobiology, hemostasis, thrombosis and autoimmune diseases.
Drug discovery research for hemophilia and in critical bleeding indications.
Development of therapeutics for spinal cord injury, multiple sclerosis and other central nervous system disorders.
Experienced with molecular and cellular pharmacology, cell-based assays with central nervous system (CNS) and immune cell types, immunohistochemistry and thrombosis pathology, animal models.

Undisclosed Company, Manager, Molecular Pharmacology, 2007 - Present

Focus on drug discovery research for hemophilia and in critical bleeding disorders: Leader of tissue biology section.
Managed and supervised histology and cell biological studies.
Managed research contracts with academic collaborators testing neuroprotective compound for stroke and traumatic brain injury.

Staff Scientist, 2005 - 2006

Acorda Therapeutics, Scientist, Hawthorne, NY, 1999 - 2005

Start-up biotech company specializing in the development of therapeutics for spinal cord injury, multiple sclerosis and other central nervous system disorders.
Led multidisciplinary teams conducting animal models for multiple sclerosis and spinal cord injury, pharmacological testing, biological assays and analytical characterization.
Worked with consultants and CROs in defining toxicology studies for FDA approval of therapeutic.
Coordinated research with academic and corporate collaborators.
Interacted with patent attorneys for due diligence analysis.
Supported drug discovery and development efforts by designing and implementing numerous functional assays.
Established cell-based assays for pre-clinical testing of drug candidates.
Designed and implemented tests for anti-inflammatory compound, including cytokine analysis.
Prepared technical reports and SOPs for pre-clinical projects.

The Rockefeller University, Research Associate, 1993 - 1998

Contributed to the understanding of basic principles underlying cellular specification in the developing mouse cerebellum.
Characterized the functional consequences of a mutant K channel in mouse cerebellar granule cells.
Conducted primary neuronal and non-neuronal cell culture.
Applied the technique of SAGE (Serial Analysis of Gene Expression) to analyze cerebellar gene expression during development.
Used a variety of molecular techniques including DNA cloning, DNA purification, PCR , Sequence analysis using BLAST.

Yale University, Postdoctoral Associate, 1991 - 1993

Studied developmental synaptic plasticity in the rodent CNS.
Analyzed the regulation of glutamate receptor genes during the development of the rat visual system.
Conducted DNA cloning, DNA purification, Northern blot analysis, RT-PCR, in situ hybridization.
Performed primary neuronal cultures.

Academic and Professional Affiliations

Publications