Pharmaceutical Consultant for Oncology Drug Discovery and Development

Expertise

• Pharmaceutical / biomedical research scientist with 34 years of experience in the area of oncology.
• Drug discovery research in the Cancer Department at Merck Research Labs.
• Demonstrated track record identifying protein targets involved in the cancer disease process and developing small molecules that inhibit their functional activity.
• Evaluate and integrate outcomes data from a variety of sources.
• Recognized as an excellent mentor and motivator of research staff and colleagues, capable of maintaining a high level of productivity and achieve program objectives.
• Developmental biology.
• Cellular biology.
• Molecular biology.
• Animal model systems (oncology).
• Cell cycle regulation - signal transduction.
• Apoptosis/survival signaling.
• Cancer target ID and validation.
• Assay and drug development (oncology).

Experience

Independent Consultant, 2009 - present

• Target ID /validation /drug discovery and development, with clients, including Locus Pharmaceuticals and GlaxoSmithkline.

GlaxoSmithkline Research Laboratories, Collegeville, PA , Manager, 2007 - 2008

• Oncology target ID and validation cell based assay development (myc, ALK, EGFR family).

Merck Research Laboratories, West Point, PA,1982 - 2007

Senior Investigator,1999 - 2007

• AKT program (led to development of MK2206).
• IGFR program.
• PSA-conjugate program.

Senior Research Fellow, 1995 - 1999

• HPV E7 oncology program.
• Apoptosis targets (caspases, Bcl2 family members).
• Rb interacting proteins.

Research Fellow, 1990 - 1995

• Growth factors and their receptors (TGFa, HER family members).
• Transcription factor signaling.
• Ras proteins for cellular signal transduction.

National Institutes of Health, Bethesda, MD, Research Associate, Laboratory of Molecular Oncology, 1978 - 1982

• Identification, cloning and expression of Ras family proteins.

Columbia University, New York, NY, Research Assistant, Department of Cancer Research, 1974 - 1978

• Development of two step carcinogenesis models.
• Tumor promotion by phorbol esters.

Honors & Publications

Academic and Professional Affiliations

• American Association for the Advancement of Science
• American Association for Cancer Research

Training

• Developmental Biology
• Cellular Biology
• Molecular Biology
• Animal Model Systems
• Cell Cycle Regulation - Signal Transduction
• Apoptosis/Survival Signaling
• Cancer Target ID / Validation / Drug Development

Publications and Patents

• 58 publications
• 7 patents

Education

• M.S. Molecular Biology, American University, Washington, DC
• B.S. Biology, SUNY at Geneseo, NY