Expert Medicinal Chemistry Consultant Specializing in Organic Medicinal Chemistry, and Patent Examination

Technical Consultant #1723

Synthetic organic chemistry, analysis of various classes of compounds, achieving successful new challenges toward a position as a Medicinal Chemistry Consultant, and Consultant in chemical marketing.
Achieved and conceived synthetic methodology for construction of difficult glycosidic bonds unachievable by conventional synthetic methods, present in many natural compounds that display interesting biological activities as anti-cancer, anti-cardiac agents.
Large scale syntheses of monosaccharides.
Experienced in process chemistry, and clean GMP laboratories - medium large scale of diverse monosaccharides for preparation of large saccharides.
Parallel synthesis, for multi-step natural product synthesis, carbohydrate synthesis and glycoconjugates.
Natural product synthesis of cyclic compounds, C-C bond formation, and asymmetric synthesis of small molecules natural products.
Synthesis of, heterocyclic compounds, modified nucleotides and nucleosides.
Air sensitive compounds manipulating, including synthesis of various compounds, and organophosphorous compounds.
Organo-metallic elements transition, (Rhodium, Cobalt, and Palladium), and organosilicons for synthesis of various natural products.
Peptide synthesis, solid phase, peptidomimetics, and racimization analysis and purification by HPLC.
Experienced in 1D-NMR, 2D-NMR (H-H COSY, C-H COSY, HMBC, TOCSY, ROESY), other analytical techniques HPLC, GC-MS, IR-UV spectroscopy.

Undisclosed Company, Canada, Medicinal Chemistry Consultant, Present

Develop; devise new efficient synthetic schemes for anti-cancer, antiviral agents, such as small molecules, heterocycles, complex intermediates for natural peptidomimetics, asymmetric synthesis of bio-active compounds that are to be carried out in company's laboratory.

Undisclosed Company, Bellevue, WA, Scientific Consultant, Organic Chemistry, 2009 - Present

Writing solution report to support scientist to promoting discoveries and inventions that can lead to a patent allowance.
Participation in various laboratory sessions, meetings with industrial and federal scientists. Scientific reviewing of novel inventions in organic and nanochemistry.

Miami Dade College, Miami, FL, Adjunct Professor - General and Organic Chemistry, 2009

Lecture and laboratory teaching for first and second year college students, pre-nursing, pre-med, pre-pharmacy, biology and chemistry.

U.S. Patent and Trademark Office, Junior Scientific Patent Examiner, 2008

Junior patent examiner in Organic Chemistry, Biotech, Pharmaceutical.
Skills of patent examining applications, inventions, search of prior art by using multiple scientific and patent search software toward finding prior art.
Use of scientific specialty to determine prior art, patentability or non-patentability of organic chemistry inventions for chemical mixtures, natural products, polymers pertaining to Biotech-Pharma.

National Institute of Child Health and Human Development, Bethesda, MD, 2006 - 2008

As a Post-Doctoral Research Fellow research project focused on the synthesis and development of polysaccharides and lipido-aminoacids adjuvant and the combination of these adjuvants with a short saccharide or polysaccharide to construct a glyco-amino lipid derivative.
Synthesis of mono-saccharides in medium-large scale synthesis in clean GMP room laboratory, to construct oligosaccharides.
Linkage of glycoamino-lipids to a carrier protein in order to stimulate cellular immune defense.

Organic Chemistry Institute, University of Tubingen, Germany, Research Associate, 2001 - 2005

Developed and devised the total stereo and region-selective synthesis of cyclic disaccharides by Intra-molecular Glycosylation, an efficient methodology to create difficult glycoside linkages present in natural glycol-conjugates; unachievable by the conventional glycosylation method.
The cyclic products can be transformed into a polysaccharide to construct polysaccharide vaccines, glycoconjugates, dendrimers of medicinal importance.

Organic Chemistry Institute, University of Lausanne, Switzerland, Research Associate, 1993

Elaborated the design, chemical synthesis, and structure-function relationships of peptide-mimetics to mimic the turn conformation for potential use in drug development.
Purification of peptide mimetics by High Performance Liquid Chromatography (HPLC) and identification by diverse spectroscopic methods.

CIBA-Geigy, Agrochemical Division, Basel Switzerland, Synthetic Organic Chemist, 1992

Achieved the asymmetric synthesis of natural products by C-C bond formation, to be tested as pesticides, and fungicides for plant protection.
Completed the purification of these compounds by column chromatography and HPLC. Cooperation with biologists to study biological activity of these compounds on plants.
Wrote laboratory protocols to conform to the company's regulations, held seminars to interpret results, and attended seminars held by Ciba-Geigy's and other company's synthetic chemist.

Credentials

Graduated Magna Cum Laude (the highest credential awarded to a foreign - non-German, Ph.D. Candidate).
Numerous software search programs for patent examining, Patent Searching East, West, AOCS, and Dialog, also extremely helpful for bibliographical chemical searches pertaining to scientific research.
Tools: PowerPoint, MS-Word, Word Perfect, Excel, Windows 1998, 2000, 2003-2007.
Utilization of chemistry program softwares such as Chemsketch, Chemwindows, Chemdraw, STN, CAPLUS file registry, file registry chemical drawings (from STN) Beilstein, Sci-Finder, NMR-programs to retrieve and process 1 and 2 dimensional NMR spectrums.

Languages

Excellent communications skills, facility to integrate in multicultural, multi-ethnic groups, multidisciplinary groups and strong international experiences.
English
French
German
Spanish
Italian
Portuguese

Academic and Professional Affiliations

Publications and Patents

Ph.D. Organic Chemistry, Institute of Organic Chemistry, University of Tubingen, Germany
M.Sc. University Paul Sabatier, Toulouse, France
B.Sc. University Paul Sabatier, Toulouse, France