Medicinal Chemistry Consultant Specializing in Drug Discovery, Drug Design, Intellectual Property Rights, Patent Application and Prosecution

Technical Consultant #1861

Technical Expertise

Biological Targets

Disease States

Intellectual Property Expertise

Expert Witness Experience

Provided written opinion and deposition concerning the art of pharmaceutical science, salt selection for pharmaceutical products, the process used to select appropriate salt forms, stability of those salt forms, and the formulation of pharmaceutical products, including controlled and modified release formulations.

Undisclosed University, 2010 - Present

Assistant Professor of Medicinal Chemistry - Center for Drug Discovery Research

Responsible for medicinal chemistry education and training of students and post-doctoral fellows, project leadership, cultivating collaborations for technology transfer, grant application authorship, design, installation and oversight of new medicinal chemistry laboratory.
Principles in drug discovery course coordinator.
Chemical screening library acquisition - Identified and acquired 40,000 compound chemical screening library for the center's research programs.
Cheminformatics database development and maintenance - Identified, installed, and maintain ChemAxon InstantJChem cheminformatics database for department.
Molecular modeling software - Managed deployment, training, and acted as local expert on Tripos Muse, Benchware, and Sybyl-X 1.3.
Internet Presence Manager - Designed, built, and implemented new website for the center's drug discovery to increase web presence and attract additional collaborators and programs.

Undisclosed Company, Owner and Patent Agent, 2010 - Present

Independent patent filing business, specializing in biotechnology and chemistry applications.
Provide intellectual property guidance to small/micro biotechnology companies.

Undisclosed Law Firm, 2011 - Present

Fox Chase Chemical Diversity Center, Doylestown, PA, Research Fellow, 2010

Responsible for medicinal chemistry project leadership, maintaining and cultivating strategic collaborations with academic institutions for technology transfer, identification and pursuit of in-licensing opportunities, grant application authorship, design, installation and oversight of new medicinal chemistry laboratory and instrumentation.
Installed Gilson 215 HPLC purification system and Biotage Initiator 60 Microwave, established fee for service program revenue stream.
Four grant applications filed (NIH, DOD).

Pfizer/Wyeth Research, Collegeville, PA, Principal Research Scientist, 2006 - 2010

Kv1.5 Blocker Team Leader: Responsible for successful integration of acquired chemical equity, discovery research effort, back-up programs, and lead progression to IND status.
TRPV1 Chemistry Senior Team Member: Responsible for chemistry team research programs, integration with biology team, and development of program equity. Provided chemical matter with improved physical properties, superior selectivity, and increased efficacy in pain models.
ER %u03B2 Chemistry Senior Team Member: Responsible for personal, independent research and direction of research associate's efforts.
Provided back-up equity with improved physical properties and superior selectivity over ER for women's health programs.

Procter & Gamble Pharmaceuticals, Cincinnati, OH, 1994 - 2006

Lead Discovery Section Group Leader: Responsible for project portfolio management, oversight of twelve chemists (B.S. and Ph.D., U.S. based and International collaborators) and team leadership on multiple programs.
Designed novel analogs, focused libraries, and high through-put synthesis for a range of biological targets including kinases, tyrosine phosphatases, GPCRs, and ion channels.
Substantial matter added to project patent filings, multiple programs moved to clinical trials/IND filing.
Building Blocks Team Leader: Responsible for personal, independent research in addition to management of five chemists dedicated to the development and preparation of intermediates for focused library synthesis (up to 1 kg).
Increased efficiency of the larger Library Synthesis Team by providing novel intermediates for directed library preparation.
Library synthesis team: Designed and prepared focused chemical libraries using parallel synthesis techniques for medicinal chemistry projects.
Responsible for management of three chemistry team members.
Heart failure drug design: Designed and synthesized a novel series of Na /K ATPase inhibitors.
Patent filed on a novel series of inotropic agents.
Corporate chemistry contact: Design and implementation of an E-commerce chemical procurement system.
Chemistry representative for contract negotiations with major laboratory suppliers.

Credentials

License

U.S. Patent Agent, registration

Academic and Professional Affiliations

Adjunct Professor, Drexel University College of Medicine Department of Pharmacology and Physiology
Editorial Advisory Board Member, Current Topics in Medicinal Chemistry
ACS Medicinal Chemistry Letters Patent Panelist
Residential School on Medicinal Chemistry, Drew University
American Chemical Society Member
American Association of College of Pharmacy Member
Reviewer for European Journal of Medicinal Chemistry, Bioorganic and Medicinal Chemistry Letters, Tetrahedron Letters, Journal of Medicinal Chemistry.
Organic Colloquium Committee Chairman
Campus Recruiter, Emory University

Publications and Patents